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Viruses 2013, 5(10), 2329-2348; doi:10.3390/v5102329
Review

Diagnosis of West Nile Virus Human Infections: Overview and Proposal of Diagnostic Protocols Considering the Results of External Quality Assessment Studies

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Received: 16 August 2013 / Revised: 28 August 2013 / Accepted: 9 September 2013 / Published: 25 September 2013
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Abstract

West Nile virus, genus Flavivirus, is transmitted between birds and occasionally other animals by ornithophilic mosquitoes. This virus also infects humans causing asymptomatic infections in about 85% of cases and <1% of clinical cases progress to severe neuroinvasive disease. The virus also presents a threat since most infections remain unapparent. However, the virus contained in blood and organs from asymptomatically infected donors can be transmitted to recipients of these infectious tissues. This paper reviews the presently available methods to achieve the laboratory diagnosis of West Nile virus infections in humans, discussing the most prominent advantages and disadvantages of each in light of the results obtained during four different External Quality Assessment studies carried out by the European Network for ‘Imported’ Viral Diseases (ENIVD).
Keywords: West Nile virus; state of the art laboratory diagnostic; external quality assurance West Nile virus; state of the art laboratory diagnostic; external quality assurance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sambri, V.; Capobianchi, M.R.; Cavrini, F.; Charrel, R.; Donoso-Mantke, O.; Escadafal, C.; Franco, L.; Gaibani, P.; Gould, E.A.; Niedrig, M.; Papa, A.; Pierro, A.; Rossini, G.; Sanchini, A.; Tenorio, A.; Varani, S.; Vázquez, A.; Vocale, C.; Zeller, H. Diagnosis of West Nile Virus Human Infections: Overview and Proposal of Diagnostic Protocols Considering the Results of External Quality Assessment Studies. Viruses 2013, 5, 2329-2348.

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