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Viruses 2013, 5(1), 87-110; doi:10.3390/v5010087

Human Metapneumovirus in Adults

1,* , 2
1 Department of Intensive Care Medicine, Diakonessenhuis, Utrecht, 3582 KE, The Netherlands 2 Department of Microbiology, Diakonessenhuis, Utrecht, 3582 KE, The Netherlands 3 Department of Pulmonary Diseases, Diakonessenhuis, Utrecht, 3582 KE, The Netherlands
* Author to whom correspondence should be addressed.
Received: 30 November 2012 / Revised: 17 December 2012 / Accepted: 19 December 2012 / Published: 8 January 2013
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
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Human metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV antibodies in humans more than 50 years earlier. Although the virus was primarily known as causative agent of respiratory tract infections in children, HMPV is an important cause of respiratory infections in adults as well. Almost all children are infected by HMPV below the age of five; the repeated infections throughout life indicate transient immunity. HMPV infections usually are mild and self-limiting, but in the frail elderly and the immunocompromised patients, the clinical course can be complicated. Since culturing the virus is relatively difficult, diagnosis is mostly based on a nucleic acid amplification test, such as reverse transcriptase polymerase chain reaction. To date, no vaccine is available and treatment is supportive. However, ongoing research shows encouraging results. The aim of this paper is to review the current literature concerning HMPV infections in adults, and discuss recent development in treatment and vaccination.
Keywords: human metapneumovirus; HMPV; respiratory tract infection; adults; intensive care; diagnosis; treatment; vaccination human metapneumovirus; HMPV; respiratory tract infection; adults; intensive care; diagnosis; treatment; vaccination
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Haas, L.E.M.; Thijsen, S.F.T.; van Elden, L.; Heemstra, K.A. Human Metapneumovirus in Adults. Viruses 2013, 5, 87-110.

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