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Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
Department of Virology, ErasmusMC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
* Author to whom correspondence should be addressed.
Received: 3 July 2012; in revised form: 10 August 2012 / Accepted: 22 August 2012 / Published: 3 September 2012
Abstract: The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
Keywords: influenza; evasion; innate immunity; adaptive immunity
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MDPI and ACS Style
van de Sandt, C.E.; Kreijtz, J.H.C.M.; Rimmelzwaan, G.F. Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses. Viruses 2012, 4, 1438-1476.
van de Sandt CE, Kreijtz JHCM, Rimmelzwaan GF. Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses. Viruses. 2012; 4(9):1438-1476.
van de Sandt, Carolien E.; Kreijtz, Joost H. C. M.; Rimmelzwaan, Guus F. 2012. "Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses." Viruses 4, no. 9: 1438-1476.