Viruses 2012, 4(8), 1335-1353; doi:10.3390/v4081335
Review

Herpesviruses Placating the Unwilling Host: Manipulation of the MHC Class II Antigen Presentation Pathway

Received: 13 July 2012; in revised form: 14 August 2012 / Accepted: 15 August 2012 / Published: 22 August 2012
(This article belongs to the Special Issue Immune Evasion)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we review, with emphasis on human herpesvirus infections, the strategies evolved to evade CD4 T cell immunity. These viruses target multiple points on the MHC class II antigen presentation pathway. The mechanisms include: suppression of CIITA to inhibit the synthesis of MHC class II molecules, diversion or degradation of HLA-DR molecules during membrane transport, and direct targeting of the invariant chain chaperone of HLA-DR.
Keywords: herpes viruses; MHC class II; CD4 T cell; immune evasion
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MDPI and ACS Style

Zuo, J.; Rowe, M. Herpesviruses Placating the Unwilling Host: Manipulation of the MHC Class II Antigen Presentation Pathway. Viruses 2012, 4, 1335-1353.

AMA Style

Zuo J, Rowe M. Herpesviruses Placating the Unwilling Host: Manipulation of the MHC Class II Antigen Presentation Pathway. Viruses. 2012; 4(8):1335-1353.

Chicago/Turabian Style

Zuo, Jianmin; Rowe, Martin. 2012. "Herpesviruses Placating the Unwilling Host: Manipulation of the MHC Class II Antigen Presentation Pathway." Viruses 4, no. 8: 1335-1353.

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