Herpesvirus Exploitation of Host Immune Inhibitory Pathways
AbstractHerpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the current understanding of inhibitory pathways in modulating antiviral immunity during herpesvirus infections in vivo and discuss strategies employed by herpesviruses to exploit these pathways to limit host antiviral immunity.
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Stack, G.; Stacey, M.A.; Humphreys, I.R. Herpesvirus Exploitation of Host Immune Inhibitory Pathways. Viruses 2012, 4, 1182-1201.
Stack G, Stacey MA, Humphreys IR. Herpesvirus Exploitation of Host Immune Inhibitory Pathways. Viruses. 2012; 4(8):1182-1201.Chicago/Turabian Style
Stack, Gabrielle; Stacey, Maria A.; Humphreys, Ian R. 2012. "Herpesvirus Exploitation of Host Immune Inhibitory Pathways." Viruses 4, no. 8: 1182-1201.