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Viruses 2012, 4(6), 924-939; doi:10.3390/v4060924

Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection

1
Service of Electrophysiology, Veterinary Medicine Teaching Hospital of the University of Buenos Aires, San Martín Av. 4453, CP 1427, Buenos Aires, Argentina
2
Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina
3
Department of Clinical Pathology. School of Veterinary Sciences, University of Buenos Aires, Buenos Aires, 1427, Argentina
4
Department of Immunology, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina
5
Pablo Cassará Laboratory, Saladillo 2452, Buenos Aires, Argentina
*
Author to whom correspondence should be addressed.
Received: 1 May 2012 / Revised: 14 May 2012 / Accepted: 24 May 2012 / Published: 30 May 2012
(This article belongs to the Special Issue Feline Retroviruses)
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Abstract

The aim of this study was to evaluate the efficacy of the antiretrovirals: Zidovudine (ZDV) alone; ZDV + Recombinant Human Interferon-α (rHuIFN-α); ZDV + Lamivudine (3TC) and ZDV + valproic acid (Valp) on naturally feline immunodeficiency virus (FIV)-infected cats, in the late phase of the asymptomatic stage of infection. The follow-up was performed over one year, through clinical evaluation and the determination of viral loads and CD4+/CD8+ ratios. Neurological signs were studied by visual and auditory evoked potentials (VEP, AEP) and the responses were abnormal in 80% of the FIV-infected cats. After one year, an improvement in VEP and AEP was observed in the ZDV + Valp group and a worsening in the group receiving ZDV + rHuIFN-α. The CD4+/CD8+ ratio showed a significant increase (both intra and inter-groups) only in ZDV and ZDV + 3TC, between their pre-treatment and one year values, as well as among the other groups. Viral load only showed a significant decrease in ZDV and ZDV + 3TC groups, when comparing the values at one year of treatment vs. pre-treatment values and when the different groups were compared. In addition, the viral load decrease was significantly more pronounced in the ZDV + 3TC vs. ZDV group. We conclude that ZDV and ZDV + 3TC produce significant reductions in viral load and stimulate a recovery of the CD4+/CD8+ ratio, compared with the other protocols. It is clear that the addition of 3TC resulted in a greater reduction in viral load than use of ZDV as a single drug. Therefore, the combination ZDV + 3TC could be more effective than the sole use of ZDV. View Full-Text
Keywords: antiretroviral therapy; FIV; retrovirus; visual and auditory evoked potentials; ZDV; 3TC; valproic acid; rHuIFN-α antiretroviral therapy; FIV; retrovirus; visual and auditory evoked potentials; ZDV; 3TC; valproic acid; rHuIFN-α
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gómez, N.V.; Fontanals, A.; Castillo, V.; Gisbert, M.A.; Suraniti, A.; Mira, G.; Pisano, P.B. Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection. Viruses 2012, 4, 924-939.

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