Viruses 2012, 4(5), 725-733; doi:10.3390/v4050725
Review

Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells

1,* email and 2email
Received: 29 March 2012; in revised form: 18 April 2012 / Accepted: 24 April 2012 / Published: 2 May 2012
(This article belongs to the Special Issue Animal Arteriviruses and Coronaviruses)
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Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules, Poly I:C. However, the mechanistic basis by which PRRSV interferes with the induction of type I interferon in its natural host cells remains less well defined. The purposes of this review are to summarize the key findings in supporting the post-transcriptional control of type I interferon in its natural host cells and to propose the possible role of translational control in the regulation of type I interferon induction by PRRSV.
Keywords: PRRSV; type I interferon; post-transcriptional regulation; translational control
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, X.; Christopher-Hennings, J. Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells. Viruses 2012, 4, 725-733.

AMA Style

Wang X, Christopher-Hennings J. Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells. Viruses. 2012; 4(5):725-733.

Chicago/Turabian Style

Wang, Xiuqing; Christopher-Hennings, Jane. 2012. "Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells." Viruses 4, no. 5: 725-733.


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