Viruses 2012, 4(5), 725-733; doi:10.3390/v4050725
Review

Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells

1 Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA 2 Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA
* Author to whom correspondence should be addressed.
Received: 29 March 2012; in revised form: 18 April 2012 / Accepted: 24 April 2012 / Published: 2 May 2012
(This article belongs to the Special Issue Animal Arteriviruses and Coronaviruses)
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Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules, Poly I:C. However, the mechanistic basis by which PRRSV interferes with the induction of type I interferon in its natural host cells remains less well defined. The purposes of this review are to summarize the key findings in supporting the post-transcriptional control of type I interferon in its natural host cells and to propose the possible role of translational control in the regulation of type I interferon induction by PRRSV.
Keywords: PRRSV; type I interferon; post-transcriptional regulation; translational control

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MDPI and ACS Style

Wang, X.; Christopher-Hennings, J. Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells. Viruses 2012, 4, 725-733.

AMA Style

Wang X, Christopher-Hennings J. Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells. Viruses. 2012; 4(5):725-733.

Chicago/Turabian Style

Wang, Xiuqing; Christopher-Hennings, Jane. 2012. "Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells." Viruses 4, no. 5: 725-733.

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