Next Article in Journal
Folding and Oligomerization of the gp2b/gp3/gp4 Spike Proteins of Equine Arteritis Virus in Vitro
Previous Article in Journal
Feline Immunodeficiency Virus in South America
Previous Article in Special Issue
Animal Models of Dengue Virus Infection
Viruses 2012, 4(3), 397-413; doi:10.3390/v4030397

Innate Immunity Evasion by Dengue Virus

Department of Microbiology and the Global Health and Emerging Pathogens Institute (GHEPI), Mount Sinai School of Medicine, New York, NY 10029-6574, USA
* Author to whom correspondence should be addressed.
Received: 30 January 2012 / Revised: 14 February 2012 / Accepted: 7 March 2012 / Published: 15 March 2012
(This article belongs to the Special Issue Recent Progress in Dengue Virus Research)
View Full-Text   |   Download PDF [880 KB, uploaded 12 May 2015]   |   Browse Figures


For viruses to productively infect their hosts, they must evade or inhibit important elements of the innate immune system, namely the type I interferon (IFN) response, which negatively influences the subsequent development of antigen-specific adaptive immunity against those viruses. Dengue virus (DENV) can inhibit both type I IFN production and signaling in susceptible human cells, including dendritic cells (DCs). The NS2B3 protease complex of DENV functions as an antagonist of type I IFN production, and its proteolytic activity is necessary for this function. DENV also encodes proteins that antagonize type I IFN signaling, including NS2A, NS4A, NS4B and NS5 by targeting different components of this signaling pathway, such as STATs. Importantly, the ability of the NS5 protein to bind and degrade STAT2 contributes to the limited host tropism of DENV to humans and non-human primates. In this review, we will evaluate the contribution of innate immunity evasion by DENV to the pathogenesis and host tropism of this virus.
Keywords: interferon antagonism; NS2B3; NS5; STAT2 degradation interferon antagonism; NS2B3; NS5; STAT2 degradation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Morrison, J.; Aguirre, S.; Fernandez-Sesma, A. Innate Immunity Evasion by Dengue Virus. Viruses 2012, 4, 397-413.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert