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Viruses 2012, 4(3), 363-382; doi:10.3390/v4030363
Article

The Coronavirus E Protein: Assembly and Beyond

 and *
Received: 24 December 2011; in revised form: 18 February 2012 / Accepted: 27 February 2012 / Published: 8 March 2012
(This article belongs to the Special Issue Animal Arteriviruses and Coronaviruses)
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Abstract: The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.
Keywords: envelope protein; coronavirus assembly; ion channel; Golgi complex; membrane protein topology envelope protein; coronavirus assembly; ion channel; Golgi complex; membrane protein topology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ruch, T.R.; Machamer, C.E. The Coronavirus E Protein: Assembly and Beyond. Viruses 2012, 4, 363-382.

AMA Style

Ruch TR, Machamer CE. The Coronavirus E Protein: Assembly and Beyond. Viruses. 2012; 4(3):363-382.

Chicago/Turabian Style

Ruch, Travis R.; Machamer, Carolyn E. 2012. "The Coronavirus E Protein: Assembly and Beyond." Viruses 4, no. 3: 363-382.


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