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Clinical Characteristics and Genetic Variability of Human Rhinovirus in Mexico
Instituto de Salud Pública, Universidad Veracruzana, Av. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, 91190, Xalapa, Veracruz, México
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, 62210, Cuernavaca, Morelos, México
Hospital Civil ‘Luis F. Nachón’, Secretaría de Salud, Pedro Rendón 1, Esq. Nicolás Bravo, 91000, Xalapa, Veracruz, México
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 15 November 2011; in revised form: 17 January 2012 / Accepted: 17 January 2012 / Published: 25 January 2012
Abstract: Human rhinovirus (HRV) is a leading cause of acute respiratory infection (ARI) in young children and infants worldwide and has a high impact on morbidity and mortality in this population. Initially, HRV was classified into two species: HRV-A and HRV-B. Recently, a species called HRV-C and possibly another species, HRV-D, were identified. In Mexico, there is little information about the role of HRV as a cause of ARI, and the presence and importance of species such as HRV-C are not known. The aim of this study was to determine the clinical characteristics and genetic variability of HRV in Mexican children. Genetic characterization was carried out by phylogenetic analysis of the 5′-nontranslated region (5′-NTR) of the HRV genome. The results show that the newly identified HRV-C is circulating in Mexican children more frequently than HRV-B but not as frequently as HRV-A, which was the most frequent species. Most of the cases of the three species of HRV were in children under 2 years of age, and all species were associated with very mild and moderate ARI.
Keywords: HRV; HRV-C; wheezing; genotyping
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Landa-Cardeña, A.; Morales-Romero, J.; García-Roman, R.; Cobián-Güemes, A.G.; Méndez, E.; Ortiz-Leon, C.; Pitalúa-Cortés, F.; Mora, S.I.; Montero, H. Clinical Characteristics and Genetic Variability of Human Rhinovirus in Mexico. Viruses 2012, 4, 200-210.
Landa-Cardeña A, Morales-Romero J, García-Roman R, Cobián-Güemes AG, Méndez E, Ortiz-Leon C, Pitalúa-Cortés F, Mora SI, Montero H. Clinical Characteristics and Genetic Variability of Human Rhinovirus in Mexico. Viruses. 2012; 4(2):200-210.
Landa-Cardeña, Adriana; Morales-Romero, Jaime; García-Roman, Rebeca; Cobián-Güemes, Ana Georgina; Méndez, Ernesto; Ortiz-Leon, Cristina; Pitalúa-Cortés, Felipe; Mora, Silvia Ivonne; Montero, Hilda. 2012. "Clinical Characteristics and Genetic Variability of Human Rhinovirus in Mexico." Viruses 4, no. 2: 200-210.