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Viruses 2012, 4(12), 3754-3784; doi:10.3390/v4123754

Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers

1,†,* , 1,†
2, 2
Received: 14 November 2012 / Revised: 10 December 2012 / Accepted: 12 December 2012 / Published: 14 December 2012
(This article belongs to the Special Issue Advances in Filovirus Research 2012)
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Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.
Keywords: Ebola; filovirus; hamster model; rodent model; pathogenesis Ebola; filovirus; hamster model; rodent model; pathogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Wahl-Jensen, V.; Bollinger, L.; Safronetz, D.; de Kok-Mercado, F.; Scott, D.P.; Ebihara, H. Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers. Viruses 2012, 4, 3754-3784.

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