Viruses 2012, 4(12), 3270-3280; doi:10.3390/v4123270
Review

Respiratory Syncytial Virus Persistence in Macrophages Alters the Profile of Cellular Gene Expression

* email and email
Received: 23 October 2012; in revised form: 14 November 2012 / Accepted: 15 November 2012 / Published: 22 November 2012
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Viruses can persistently infect differentiated cells through regulation of expression of both their own genes and those of the host cell, thereby evading detection by the host’s immune system and achieving residence in a non-lytic state. Models in vitro with cell lines are useful tools in understanding the mechanisms associated with the establishment of viral persistence. In particular, a model to study respiratory syncytial virus (RSV) persistence in a murine macrophage-like cell line has been established. Compared to non-infected macrophages, macrophages persistently infected with RSV show altered expression both of genes coding for cytokines and trans-membrane proteins associated with antigen uptake and of genes related to cell survival. The biological changes associated with altered gene expression in macrophages as a consequence of persistent RSV infection are summarized.
Keywords: respiratory syncytial virus; viral persistence; macrophages; P388D1; altered gene expression
PDF Full-text Download PDF Full-Text [400 KB, uploaded 22 November 2012 14:03 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Rivera-Toledo, E.; Gómez, B. Respiratory Syncytial Virus Persistence in Macrophages Alters the Profile of Cellular Gene Expression. Viruses 2012, 4, 3270-3280.

AMA Style

Rivera-Toledo E, Gómez B. Respiratory Syncytial Virus Persistence in Macrophages Alters the Profile of Cellular Gene Expression. Viruses. 2012; 4(12):3270-3280.

Chicago/Turabian Style

Rivera-Toledo, Evelyn; Gómez, Beatríz. 2012. "Respiratory Syncytial Virus Persistence in Macrophages Alters the Profile of Cellular Gene Expression." Viruses 4, no. 12: 3270-3280.


Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert