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Viruses 2012, 4(11), 2736-2753; doi:10.3390/v4112736
Article

Dendritic Cell Apoptosis and the Pathogenesis of Dengue

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Received: 12 October 2012 / Revised: 30 October 2012 / Accepted: 31 October 2012 / Published: 1 November 2012
(This article belongs to the Special Issue Modulation of Apoptosis by Viral Infection)
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Abstract

Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.
Keywords: Dendritic cell; apoptosis; dengue virus Dendritic cell; apoptosis; dengue virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Martins, S.T.; Silveira, G.F.; Alves, L.R.; dos Santos, C.N.D.; Bordignon, J. Dendritic Cell Apoptosis and the Pathogenesis of Dengue. Viruses 2012, 4, 2736-2753.

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