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Dendritic Cell Apoptosis and the Pathogenesis of Dengue
AbstractDengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.
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Martins, S.T.; Silveira, G.F.; Alves, L.R.; dos Santos, C.N.D.; Bordignon, J. Dendritic Cell Apoptosis and the Pathogenesis of Dengue. Viruses 2012, 4, 2736-2753.View more citation formats
Martins ST, Silveira GF, Alves LR, dos Santos CND, Bordignon J. Dendritic Cell Apoptosis and the Pathogenesis of Dengue. Viruses. 2012; 4(11):2736-2753.Chicago/Turabian Style
Martins, Sharon T.; Silveira, Guilherme F.; Alves, Lysangela R.; dos Santos, Claudia N.D.; Bordignon, Juliano. 2012. "Dendritic Cell Apoptosis and the Pathogenesis of Dengue." Viruses 4, no. 11: 2736-2753.