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Dendritic Cell Apoptosis and the Pathogenesis of Dengue
Laboratory of Molecular Virology of the Carlos Chagas Institute, ICC/Fiocruz, Prof. Algacyr Munhoz Mader Street 3775, CIC, Curitiba, Paraná, 81350-010, Brazil
Laboratory of Gene Expression Regulation of the Carlos Chagas Institute, ICC/Fiocruz, Prof. Algacyr Munhoz Mader Street 3775, CIC, Curitiba, Paraná, 81350-010, Brazil
* Author to whom correspondence should be addressed.
Received: 12 October 2012; in revised form: 30 October 2012 / Accepted: 31 October 2012 / Published: 1 November 2012
Abstract: Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.
Keywords: Dendritic cell; apoptosis; dengue virus
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Martins, S.T.; Silveira, G.F.; Alves, L.R.; dos Santos, C.N.D.; Bordignon, J. Dendritic Cell Apoptosis and the Pathogenesis of Dengue. Viruses 2012, 4, 2736-2753.
Martins ST, Silveira GF, Alves LR, dos Santos CND, Bordignon J. Dendritic Cell Apoptosis and the Pathogenesis of Dengue. Viruses. 2012; 4(11):2736-2753.
Martins, Sharon T.; Silveira, Guilherme F.; Alves, Lysangela R.; dos Santos, Claudia N.D.; Bordignon, Juliano. 2012. "Dendritic Cell Apoptosis and the Pathogenesis of Dengue." Viruses 4, no. 11: 2736-2753.