Abstract: The immune system plays a major role in protecting the host against viral infection. Rapid initial protection is conveyed by innate immune cells, while adaptive immunity (including T lymphocytes) requires several days to develop, yet provides high specificity and long-lasting memory. Invariant natural killer T (iNKT) cells are an unusual subset of T lymphocytes, expressing a semi-invariant T cell receptor together with markers of the innate NK cell lineage. Activated iNKT cells can exert direct cytolysis and can rapidly release a variety of immune-polarizing cytokines, thereby regulating the ensuing adaptive immune response. iNKT cells recognize lipids in the context of the antigen-presenting molecule CD1d. Intriguingly, CD1d-restricted iNKT cells appear to play a critical role in anti-viral defense: increased susceptibility to disseminated viral infections is observed both in patients with iNKT cell deficiency as well as in CD1d- and iNKT cell-deficient mice. Moreover, viruses have recently been found to use sophisticated strategies to withstand iNKT cell-mediated elimination. This review focuses on CD1d-restricted lipid presentation and the strategies viruses deploy to subvert this pathway.
Keywords: CD1d; iNKT cells; immune evasion; viruses; antigen presentation
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Horst, D.; Geerdink, R.J.; Gram, A.M.; Stoppelenburg, A.J.; Ressing, M.E. Hiding Lipid Presentation: Viral Interference with CD1d-Restricted Invariant Natural Killer T (iNKT) Cell Activation. Viruses 2012, 4, 2379-2399.
Horst D, Geerdink RJ, Gram AM, Stoppelenburg AJ, Ressing ME. Hiding Lipid Presentation: Viral Interference with CD1d-Restricted Invariant Natural Killer T (iNKT) Cell Activation. Viruses. 2012; 4(10):2379-2399.
Horst, Daniëlle; Geerdink, Ruben J.; Gram, Anna M.; Stoppelenburg, Arie J.; Ressing, Maaike E. 2012. "Hiding Lipid Presentation: Viral Interference with CD1d-Restricted Invariant Natural Killer T (iNKT) Cell Activation." Viruses 4, no. 10: 2379-2399.