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The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection
Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA
Department of Pathology, University of Oklahoma Baboon Research Resource, University of Oklahoma, Ft. Reno Science Park, OK, USA
* Author to whom correspondence should be addressed.
Received: 8 October 2012; in revised form: 17 October 2012 / Accepted: 17 October 2012 / Published: 23 October 2012
Abstract: Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will summarize what is known about the pathogenesis of EBOV infection in baboons compared to EBOV infection in humans and other Old World nonhuman primates. In addition, we will discuss how closely the baboon model recapitulates human EBOV infection. We will also review some of the housing requirements and behavioral attributes of baboons compared to other Old World nonhuman primates. Due to the lack of data available on the pathogenesis of Marburg virus (MARV) infection in baboons, discussion of the pathogenesis of MARV infection in baboons will be limited.
Keywords: Filoviridae; Filovirus; Baboon; Papio spp.; Ebola virus; Marburg virus; BSL-4
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MDPI and ACS Style
Perry, D.L.; Bollinger, L.; L.White, G. The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection. Viruses 2012, 4, 2400-2416.
Perry DL, Bollinger L, L.White G. The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection. Viruses. 2012; 4(10):2400-2416.
Perry, Donna L.; Bollinger, Laura; L.White, Gary. 2012. "The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection." Viruses 4, no. 10: 2400-2416.