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Viruses 2012, 4(10), 2049-2079; doi:10.3390/v4102049
Review

Molecular Mechanism of Arenavirus Assembly and Budding

 and
Received: 3 August 2012; in revised form: 25 September 2012 / Accepted: 28 September 2012 / Published: 10 October 2012
(This article belongs to the Special Issue Arenaviruses)
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Abstract: Arenaviruses have a bisegmented negative-strand RNA genome, which encodes four viral proteins: GP and NP by the S segment and L and Z by the L segment. These four viral proteins possess multiple functions in infection, replication and release of progeny viruses from infected cells. The small RING finger protein, Z protein is a matrix protein that plays a central role in viral assembly and budding. Although all arenaviruses encode Z protein, amino acid sequence alignment showed a huge variety among the species, especially at the C-terminus where the L-domain is located. Recent publications have demonstrated the interactions between viral protein and viral protein, and viral protein and host cellular protein, which facilitate transportation and assembly of viral components to sites of virus egress. This review presents a summary of current knowledge regarding arenavirus assembly and budding, in comparison with other enveloped viruses. We also refer to the restriction of arenavirus production by the antiviral cellular factor, Tetherin/BST-2.
Keywords: arenavirus; assembly; budding arenavirus; assembly; budding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Urata, S.; Yasuda, J. Molecular Mechanism of Arenavirus Assembly and Budding. Viruses 2012, 4, 2049-2079.

AMA Style

Urata S, Yasuda J. Molecular Mechanism of Arenavirus Assembly and Budding. Viruses. 2012; 4(10):2049-2079.

Chicago/Turabian Style

Urata, Shuzo; Yasuda, Jiro. 2012. "Molecular Mechanism of Arenavirus Assembly and Budding." Viruses 4, no. 10: 2049-2079.


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