Viruses 2012, 4(10), 2080-2096; doi:10.3390/v4102080
Review

HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues

1,* email and 1,2email
Received: 2 August 2012; in revised form: 18 September 2012 / Accepted: 7 October 2012 / Published: 10 October 2012
(This article belongs to the Special Issue HIV Dynamics and Evolution)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The dynamics of HIV–1 viremia is a complex and evolving landscape with clinical and epidemiological (public health) implications. Most studies have relied on the use of set–point viral load (VL) as a readily available proxy of viral dynamics to assess host and viral correlates. This review highlights recent findings from population–based studies of set–point VL, focusing primarily on robust data related to host genetics. A comprehensive understanding of viral dynamics will clearly need to consider both host and viral characteristics, with close attention to (i) the timing of VL measurements, (ii) the biology of viral evolution, (iii) compartments of active viral replication, (iv) the transmission source partner as the immediate past microenvironment, and (v) proper application of statistical models.
Keywords: Correlates; genetics; HIV–1; viral load
PDF Full-text Download PDF Full-Text [414 KB, uploaded 23 October 2012 14:13 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Prentice, H.A.; Tang, J. HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues. Viruses 2012, 4, 2080-2096.

AMA Style

Prentice HA, Tang J. HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues. Viruses. 2012; 4(10):2080-2096.

Chicago/Turabian Style

Prentice, Heather A.; Tang, Jianming. 2012. "HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues." Viruses 4, no. 10: 2080-2096.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert