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Cell Surface Markers in HTLV-1 Pathogenesis
Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany
* Author to whom correspondence should be addressed.
Received: 7 July 2011; in revised form: 25 July 2011 / Accepted: 8 August 2011 / Published: 16 August 2011
Abstract: The phenotype of HTLV-1-transformed CD4+ T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine receptors, and adhesion molecules on HTLV-1-transformed cells. These molecules may provide survival signals for the transformed cells. Expression of characteristic surface markers might therefore contribute to persistence of HTLV-1-transformed lymphocytes and to the development of HTLV-1-associated disease.
Keywords: HTLV-1; Tax; oncoprotein; phenotype; differentiation; ATLL; HAM/TSP; TNFR; cytokine receptor; interleukin
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MDPI and ACS Style
Kress, A.K.; Grassmann, R.; Fleckenstein, B. Cell Surface Markers in HTLV-1 Pathogenesis. Viruses 2011, 3, 1439-1459.
Kress AK, Grassmann R, Fleckenstein B. Cell Surface Markers in HTLV-1 Pathogenesis. Viruses. 2011; 3(8):1439-1459.
Kress, Andrea K.; Grassmann, Ralph; Fleckenstein, Bernhard. 2011. "Cell Surface Markers in HTLV-1 Pathogenesis." Viruses 3, no. 8: 1439-1459.