Viruses 2011, 3(8), 1439-1459; doi:10.3390/v3081439

Cell Surface Markers in HTLV-1 Pathogenesis

* email,  and email
Received: 7 July 2011; in revised form: 25 July 2011 / Accepted: 8 August 2011 / Published: 16 August 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The phenotype of HTLV-1-transformed CD4+ T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine receptors, and adhesion molecules on HTLV-1-transformed cells. These molecules may provide survival signals for the transformed cells. Expression of characteristic surface markers might therefore contribute to persistence of HTLV-1-transformed lymphocytes and to the development of HTLV-1-associated disease.
Keywords: HTLV-1; Tax; oncoprotein; phenotype; differentiation; ATLL; HAM/TSP; TNFR; cytokine receptor; interleukin
PDF Full-text Download PDF Full-Text [484 KB, uploaded 16 August 2011 16:07 CEST]

Export to BibTeX |

MDPI and ACS Style

Kress, A.K.; Grassmann, R.; Fleckenstein, B. Cell Surface Markers in HTLV-1 Pathogenesis. Viruses 2011, 3, 1439-1459.

AMA Style

Kress AK, Grassmann R, Fleckenstein B. Cell Surface Markers in HTLV-1 Pathogenesis. Viruses. 2011; 3(8):1439-1459.

Chicago/Turabian Style

Kress, Andrea K.; Grassmann, Ralph; Fleckenstein, Bernhard. 2011. "Cell Surface Markers in HTLV-1 Pathogenesis." Viruses 3, no. 8: 1439-1459.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert