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Viruses 2011, 3(7), 1210-1248; doi:10.3390/v3071210
Review

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

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Received: 21 May 2011; in revised form: 28 June 2011 / Accepted: 29 June 2011 / Published: 19 July 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
Download PDF [306 KB, uploaded 19 July 2011]
Abstract: Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
Keywords: BLV; therapeutics; vaccines; epigenetic; eradication; control BLV; therapeutics; vaccines; epigenetic; eradication; control
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rodríguez, S.M.; Florins, A.; Gillet, N.; De Brogniez, A.; Sánchez-Alcaraz, M.T.; Boxus, M.; Boulanger, F.; Gutiérrez, G.; Trono, K.; Alvarez, I.; Vagnoni, L.; Willems, L. Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses 2011, 3, 1210-1248.

AMA Style

Rodríguez SM, Florins A, Gillet N, De Brogniez A, Sánchez-Alcaraz MT, Boxus M, Boulanger F, Gutiérrez G, Trono K, Alvarez I, Vagnoni L, Willems L. Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses. 2011; 3(7):1210-1248.

Chicago/Turabian Style

Rodríguez, Sabrina M.; Florins, Arnaud; Gillet, Nicolas; De Brogniez, Alix; Sánchez-Alcaraz, María Teresa; Boxus, Mathieu; Boulanger, Fanny; Gutiérrez, Gerónimo; Trono, Karina; Alvarez, Irene; Vagnoni, Lucas; Willems, Luc. 2011. "Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV." Viruses 3, no. 7: 1210-1248.


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