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Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV
Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), 4000, Liège, Belgium
Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Liège (ULg), 5030, Gembloux, Belgium
Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina
* Author to whom correspondence should be addressed.
Received: 21 May 2011; in revised form: 28 June 2011 / Accepted: 29 June 2011 / Published: 19 July 2011
Abstract: Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
Keywords: BLV; therapeutics; vaccines; epigenetic; eradication; control
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Rodríguez, S.M.; Florins, A.; Gillet, N.; De Brogniez, A.; Sánchez-Alcaraz, M.T.; Boxus, M.; Boulanger, F.; Gutiérrez, G.; Trono, K.; Alvarez, I.; Vagnoni, L.; Willems, L. Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses 2011, 3, 1210-1248.
Rodríguez SM, Florins A, Gillet N, De Brogniez A, Sánchez-Alcaraz MT, Boxus M, Boulanger F, Gutiérrez G, Trono K, Alvarez I, Vagnoni L, Willems L. Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses. 2011; 3(7):1210-1248.
Rodríguez, Sabrina M.; Florins, Arnaud; Gillet, Nicolas; De Brogniez, Alix; Sánchez-Alcaraz, María Teresa; Boxus, Mathieu; Boulanger, Fanny; Gutiérrez, Gerónimo; Trono, Karina; Alvarez, Irene; Vagnoni, Lucas; Willems, Luc. 2011. "Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV." Viruses 3, no. 7: 1210-1248.