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Viruses 2011, 3(7), 1210-1248; doi:10.3390/v3071210

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

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 and 1,2,*
1 Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), 4000, Liège, Belgium 2 Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Liège (ULg), 5030, Gembloux, Belgium 3 Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina
* Author to whom correspondence should be addressed.
Received: 21 May 2011 / Revised: 28 June 2011 / Accepted: 29 June 2011 / Published: 19 July 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
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Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
Keywords: BLV; therapeutics; vaccines; epigenetic; eradication; control BLV; therapeutics; vaccines; epigenetic; eradication; control
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rodríguez, S.M.; Florins, A.; Gillet, N.; De Brogniez, A.; Sánchez-Alcaraz, M.T.; Boxus, M.; Boulanger, F.; Gutiérrez, G.; Trono, K.; Alvarez, I.; Vagnoni, L.; Willems, L. Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses 2011, 3, 1210-1248.

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