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Viruses 2011, 3(6), 829-857; doi:10.3390/v3060829
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Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

1
,
2,3
 and
1,*
Received: 14 May 2011 / Revised: 31 May 2011 / Accepted: 1 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
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Abstract

The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
Keywords: HTLV-1; Tax; retrovirus; signal transduction; NF-kB; nuclear bodies; intracellular trafficking; posttranslational modifications; leukemia HTLV-1; Tax; retrovirus; signal transduction; NF-kB; nuclear bodies; intracellular trafficking; posttranslational modifications; leukemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lodewick, J.; Lamsoul, I.; Bex, F. Move or Die: the Fate of the Tax Oncoprotein of HTLV-1. Viruses 2011, 3, 829-857.

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