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Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
Institut de Recherches Microbiologiques J-M Wiame, Université Libre de Bruxelles, Avenue E. Gryson 1, B-1070 Bruxelles, Belgium
Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 route de de Narbonne, Toulouse 31077, France
Institut de Pharmacologie et de Biologie Structurale, Université Paul Sabatier, Université de Toulouse, Toulouse 31400, France
* Author to whom correspondence should be addressed.
Received: 14 May 2011; in revised form: 31 May 2011 / Accepted: 1 June 2011 / Published: 15 June 2011
Abstract: The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
Keywords: HTLV-1; Tax; retrovirus; signal transduction; NF-kB; nuclear bodies; intracellular trafficking; posttranslational modifications; leukemia
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Cite This Article
MDPI and ACS Style
Lodewick, J.; Lamsoul, I.; Bex, F. Move or Die: the Fate of the Tax Oncoprotein of HTLV-1. Viruses 2011, 3, 829-857.
Lodewick J, Lamsoul I, Bex F. Move or Die: the Fate of the Tax Oncoprotein of HTLV-1. Viruses. 2011; 3(6):829-857.
Lodewick, Julie; Lamsoul, Isabelle; Bex, Françoise. 2011. "Move or Die: the Fate of the Tax Oncoprotein of HTLV-1." Viruses 3, no. 6: 829-857.