- freely available
Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
AbstractThe HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
Share & Cite This Article
Export to BibTeX | EndNote
MDPI and ACS Style
Lodewick, J.; Lamsoul, I.; Bex, F. Move or Die: the Fate of the Tax Oncoprotein of HTLV-1. Viruses 2011, 3, 829-857.View more citation formats
Lodewick J, Lamsoul I, Bex F. Move or Die: the Fate of the Tax Oncoprotein of HTLV-1. Viruses. 2011; 3(6):829-857.Chicago/Turabian Style
Lodewick, Julie; Lamsoul, Isabelle; Bex, Françoise. 2011. "Move or Die: the Fate of the Tax Oncoprotein of HTLV-1." Viruses 3, no. 6: 829-857.