Next Article in Journal
West Nile Virus: Immunity and Pathogenesis
Next Article in Special Issue
Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
Previous Article in Journal / Special Issue
New Insights into HTLV-1 Particle Structure, Assembly, and Gag-Gag Interactions in Living Cells
Viruses 2011, 3(6), 794-810; doi:10.3390/v3060794

Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors

1 Basic Science Program, SAIC-Frederick, Inc., NCI-Frederick, Maryland, MD 21702, USA 2 INSERM, U1016, Institut Cochin, 22 rue Mechain, 75014, Paris, France 3 CNRS, UMR8104, 75014, Paris, France 4 Université Paris Descartes, 75006, Paris, France 5 Cancer and Inflammation Program, NCI-Frederick, Frederick, Maryland, MD 21702, USA 6 Service d’Hématologie Adulte, Hôpital Necker, 75743, Paris CEDEX 15, France
* Author to whom correspondence should be addressed.
Received: 20 April 2011 / Revised: 20 May 2011 / Accepted: 23 May 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
Download PDF [536 KB, uploaded 12 May 2015]


The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions with three different molecules: heparan sulfate proteoglycans (HSPG), the VEGF-165 receptor Neuropilin 1 (NRP-1) and glucose transporter type 1 (GLUT1). Here, we revisit previously published data on the functional domains of Env in regard to the recent knowledge acquired about this multi-receptor complex. We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage.
Keywords: retrovirus; viral entry; Env; proteoglycans; neuropilin; GLUT retrovirus; viral entry; Env; proteoglycans; neuropilin; GLUT
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Jones, K.S.; Lambert, S.; Bouttier, M.; Bénit, L.; Ruscetti, F.W.; Hermine, O.; Pique, C. Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors. Viruses 2011, 3, 794-810.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert