Next Article in Journal / Special Issue
Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?
Previous Article in Journal
Gammaretroviral Vectors: Biology, Technology and Application
Previous Article in Special Issue
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
Viruses 2011, 3(6), 714-749; doi:10.3390/v3060714
Review

Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis

1,2,*  and 1,2,*
Received: 2 April 2011 / Revised: 13 May 2011 / Accepted: 1 June 2011 / Published: 10 June 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
Download PDF [559 KB, uploaded 12 May 2015]

Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL), whereas the highly related HTLV-2 is not associated with ATL or other cancers. In addition to ATL leukemogenesis, studies of the HTLV viruses also provide an exceptional model for understanding basic pathogenic mechanisms of virus-host interactions and human oncogenesis. Accumulating evidence suggests that the viral regulatory protein Tax and host inflammatory transcription factor NF-kB are largely responsible for the different pathogenic potentials of HTLV-1 and HTLV-2. Here, we discuss the molecular mechanisms of HTLV-1 oncogenic pathogenesis with a focus on the interplay between the Tax oncoprotein and NF-κB pro-oncogenic signaling. We also outline some of the most intriguing and outstanding questions in the fields of HTLV and NF-κB. Answers to those questions will greatly advance our understanding of ATL leukemogenesis and other NF-κB-associated tumorigenesis and will help us design personalized cancer therapies.
Keywords: ATL; IKK; HTLV; immune escape; NF-κB; PDLIM2; Tax; transformation; tumorigenesis; virus-host interaction; WWOX ATL; IKK; HTLV; immune escape; NF-κB; PDLIM2; Tax; transformation; tumorigenesis; virus-host interaction; WWOX
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Qu, Z.; Xiao, G. Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis. Viruses 2011, 3, 714-749.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert