Next Article in Journal
Flavivirus Cell Entry and Membrane Fusion
Next Article in Special Issue
Retroviral Vectors: Post Entry Events and Genomic Alterations
Previous Article in Journal
What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation?
Article Menu

Article Versions

Export Article

Open AccessReview
Viruses 2011, 3(2), 132-159; doi:10.3390/v3020132

The Inside Out of Lentiviral Vectors

Department of Human Virology, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France
INSERM U758, 46 Allée d’Italie, 69364 Lyon, France
University of Lyon 1, 50 Avenue Tony Garnier, 69364 Lyon, France
IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, 69364 Lyon, France
Author to whom correspondence should be addressed.
Received: 26 November 2010 / Revised: 25 January 2011 / Accepted: 8 February 2011 / Published: 14 February 2011
(This article belongs to the Special Issue Retroviral Vectors)
Download PDF [347 KB, uploaded 12 May 2015]


Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.
Keywords: lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Durand, S.; Cimarelli, A. The Inside Out of Lentiviral Vectors. Viruses 2011, 3, 132-159.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top