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The Inside Out of Lentiviral Vectors
AbstractLentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.
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Durand, S.; Cimarelli, A. The Inside Out of Lentiviral Vectors. Viruses 2011, 3, 132-159.View more citation formats
Durand S, Cimarelli A. The Inside Out of Lentiviral Vectors. Viruses. 2011; 3(2):132-159.Chicago/Turabian Style
Durand, Stéphanie; Cimarelli, Andrea. 2011. "The Inside Out of Lentiviral Vectors." Viruses 3, no. 2: 132-159.