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Viruses 2011, 3(2), 132-159; doi:10.3390/v3020132

The Inside Out of Lentiviral Vectors

1 Department of Human Virology, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France 2 INSERM U758, 46 Allée d’Italie, 69364 Lyon, France 3 University of Lyon 1, 50 Avenue Tony Garnier, 69364 Lyon, France 4 IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, 69364 Lyon, France
* Author to whom correspondence should be addressed.
Received: 26 November 2010 / Revised: 25 January 2011 / Accepted: 8 February 2011 / Published: 14 February 2011
(This article belongs to the Special Issue Retroviral Vectors)
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Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.
Keywords: lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Durand, S.; Cimarelli, A. The Inside Out of Lentiviral Vectors. Viruses 2011, 3, 132-159.

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