Viruses 2010, 2(1), 1-26; doi:10.3390/v2010001
Review

Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery

1email, 1email, 2email, 3email and 1,* email
Received: 28 September 2009; in revised form: 5 December 2009 / Accepted: 17 December 2009 / Published: 6 January 2010
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Technological advances and increasingly cost-effect methodologies in DNA sequencing and computational analysis are providing genome and proteome data for human adenovirus research. Applying these tools, data and derived knowledge to the development of vaccines against these pathogens will provide effective prophylactics. The same data and approaches can be applied to vector development for gene delivery in gene therapy and vaccine delivery protocols. Examination of several field strain genomes and their analyses provide examples of data that are available using these approaches. An example of the development of HAdV-B3 both as a vaccine and also as a vector is presented.
Keywords: genomics; bioinformatics; molecular evolution; pathoepidemiology; field strain; adenovirus vaccine; human gene therapy vector; vaccine delivery vector
PDF Full-text Download PDF Full-Text [485 KB, uploaded 6 January 2010 09:38 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Seto, J.; Walsh, M.P.; Mahadevan, P.; Zhang, Q.; Seto, D. Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery. Viruses 2010, 2, 1-26.

AMA Style

Seto J, Walsh MP, Mahadevan P, Zhang Q, Seto D. Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery. Viruses. 2010; 2(1):1-26.

Chicago/Turabian Style

Seto, Jason; Walsh, Michael P.; Mahadevan, Padmanabhan; Zhang, Qiwei; Seto, Donald. 2010. "Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery." Viruses 2, no. 1: 1-26.


Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert