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Viruses 2018, 10(9), 491; https://doi.org/10.3390/v10090491

External Quality Assessment (EQA) for Molecular Diagnostics of Zika Virus: Experiences from an International EQA Programme, 2016–2018

1
Quality Control for Molecular Diagnostics (QCMD), Unit 5, Technology Terrace, Todd Campus, West of Scotland Science Park, Glasgow G20 0XA, UK
2
Division of Virology, Paul-Ehrlich-Institut (PEI), Federal Institute for Vaccines and Biomedicines, 63225 Langen, Germany
3
Robert Koch-Institut (RKI), 13353 Berlin, Germany
*
Author to whom correspondence should be addressed.
Received: 27 July 2018 / Revised: 10 September 2018 / Accepted: 12 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
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Abstract

Quality Control for Molecular Diagnostics (QCMD), an international provider for External Quality Assessment (EQA) programmes, has introduced a programme for molecular diagnostics of Zika virus (ZIKV) in 2016, which has been continuously offered to interested laboratories since that time. The EQA schemes provided from 2016 to 2018 revealed that 86.7% (92/106), 82.4% (89/108), and 88.2% (90/102) of the participating laboratories reported correct results for all samples, respectively in 2016, 2017, and 2018. The review of results indicated a need for improvement concerning analytical sensitivity and specificity of the test methods. Comparison with the outcomes of other EQA initiatives briefly summarized here show that continuous quality assurance is important to improve laboratory performance and to increase preparedness with reliable diagnostic assays for effective patient management, infection and outbreak control. View Full-Text
Keywords: Zika virus; mosquito-borne flavivirus; emerging arbovirus; outbreak control; molecular diagnostics; laboratory preparedness; assay standardization; external quality assessment; EQA; QCMD Zika virus; mosquito-borne flavivirus; emerging arbovirus; outbreak control; molecular diagnostics; laboratory preparedness; assay standardization; external quality assessment; EQA; QCMD
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Donoso Mantke, O.; McCulloch, E.; Wallace, P.S.; Yue, C.; Baylis, S.A.; Niedrig, M. External Quality Assessment (EQA) for Molecular Diagnostics of Zika Virus: Experiences from an International EQA Programme, 2016–2018. Viruses 2018, 10, 491.

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