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Viruses 2018, 10(6), 327; https://doi.org/10.3390/v10060327

The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity

1
Department of Microbiology, Institut Pasteur, F-75015 Paris, France
2
Collège Doctoral, Sorbonne Université, F-75005 Paris, France
*
Author to whom correspondence should be addressed.
Received: 18 May 2018 / Revised: 8 June 2018 / Accepted: 11 June 2018 / Published: 15 June 2018
(This article belongs to the Special Issue Hurdles for Phage Therapy (PT) to Become a Reality)
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Abstract

Phage therapy is based on a simple concept: the use of a virus (bacteriophage) that is capable of killing specific pathogenic bacteria to treat bacterial infections. Since the pioneering work of Félix d’Herelle, bacteriophages (phages) isolated in vitro have been shown to be of therapeutic value. Over decades of study, a large number of rather complex mechanisms that are used by phages to hijack bacterial resources and to produce their progeny have been deciphered. While these mechanisms have been identified and have been studied under optimal conditions in vitro, much less is known about the requirements for successful viral infections in relevant natural conditions. This is particularly true in the context of phage therapy. Here, we highlight the parameters affecting phage replication in both in vitro and in vivo environments, focusing, in particular, on the mammalian digestive tract. We propose avenues for increasing the knowledge-guided implementation of phages as therapeutic tools. View Full-Text
Keywords: virus–host interactions; bacteriophage efficacy; gastrointestinal tract; phage therapy virus–host interactions; bacteriophage efficacy; gastrointestinal tract; phage therapy
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Lourenço, M.; De Sordi, L.; Debarbieux, L. The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity. Viruses 2018, 10, 327.

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