Epigenetic Modulation of CD8+ T Cell Function in Lentivirus Infections: A Review
AbstractCD8+ T cells are critical for controlling viremia during human immunodeficiency virus (HIV) infection. These cells produce cytolytic factors and antiviral cytokines that eliminate virally- infected cells. During the chronic phase of HIV infection, CD8+ T cells progressively lose their proliferative capacity and antiviral functions. These dysfunctional cells are unable to clear the productively infected and reactivated cells, representing a roadblock in HIV cure. Therefore, mechanisms to understand CD8+ T cell dysfunction and strategies to boost CD8+ T cell function need to be investigated. Using the feline immunodeficiency virus (FIV) model for lentiviral persistence, we have demonstrated that CD8+ T cells exhibit epigenetic changes such as DNA demethylation during the course of infection as compared to uninfected cats. We have also demonstrated that lentivirus-activated CD4+CD25+ T regulatory cells induce forkhead box P3 (Foxp3) expression in virus-specific CD8+ T cell targets, which binds the interleukin (IL)-2, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ promoters in these CD8+ T cells. Finally, we have reported that epigenetic modulation reduces Foxp3 binding to these promoter regions. This review compares and contrasts our current understanding of CD8+ T cell epigenetics and mechanisms of lymphocyte suppression during the course of lentiviral infection for two animal models, FIV and simian immunodeficiency virus (SIV). View Full-Text
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Nag, M.; De Paris, K.; E. Fogle, J. Epigenetic Modulation of CD8+ T Cell Function in Lentivirus Infections: A Review. Viruses 2018, 10, 227.
Nag M, De Paris K, E. Fogle J. Epigenetic Modulation of CD8+ T Cell Function in Lentivirus Infections: A Review. Viruses. 2018; 10(5):227.Chicago/Turabian Style
Nag, Mukta; De Paris, Kristina; E. Fogle, Jonathan. 2018. "Epigenetic Modulation of CD8+ T Cell Function in Lentivirus Infections: A Review." Viruses 10, no. 5: 227.
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