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Viruses 2018, 10(2), 96; https://doi.org/10.3390/v10020096

The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut

1
Department of Food Biotechnology, Institute of Agrochemistry and Food Technology (IATA, CSIC), Av Catedrático Agustín Escardino, 7, 46980 Paterna, Spain
2
Departament of Microbiology, Faculty of Medicine, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 20 February 2018 / Accepted: 22 February 2018 / Published: 24 February 2018
(This article belongs to the Special Issue Viruses–Bacteria Interactions in the Gut)
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Abstract

Rotavirus (RV) and norovirus (NoV) are the major etiological agents of viral acute gastroenteritis worldwide. Host genetic factors, the histo-blood group antigens (HBGA), are associated with RV and NoV susceptibility and recent findings additionally point to HBGA as a factor modulating the intestinal microbial composition. In vitro and in vivo experiments in animal models established that the microbiota enhances RV and NoV infection, uncovering a triangular interplay between RV and NoV, host glycobiology, and the intestinal microbiota that ultimately influences viral infectivity. Studies on the microbiota composition in individuals displaying different RV and NoV susceptibilities allowed the identification of potential bacterial biomarkers, although mechanistic data on the virus–host–microbiota relation are still needed. The identification of the bacterial and HBGA interactions that are exploited by RV and NoV would place the intestinal microbiota as a new target for alternative therapies aimed at preventing and treating viral gastroenteritis. View Full-Text
Keywords: rotavirus; norovirus; secretor; fucosyltransferase-2 gene (FUT2); histo-blood group antigens (HBGAs); microbiota; host susceptibility rotavirus; norovirus; secretor; fucosyltransferase-2 gene (FUT2); histo-blood group antigens (HBGAs); microbiota; host susceptibility
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Monedero, V.; Buesa, J.; Rodríguez-Díaz, J. The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut. Viruses 2018, 10, 96.

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