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Viruses 2018, 10(2), 76; doi:10.3390/v10020076

RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution

Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurgaon 122413, India
ICAR National Research Centre for Banana, Thayanur Post, Tiruchirapalli 620102, India
Authors to whom correspondence should be addressed.
Received: 27 November 2017 / Revised: 30 January 2018 / Accepted: 3 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Structure-Function Relationships in Viral Polymerases)
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RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences. The structure of RdRp resembles that of a cupped right hand and consists of fingers, palm and thumb subdomains. The catalysis involves the participation of conserved aspartates and divalent metal ions. Complexes of RdRps with substrates, inhibitors and metal ions provide a comprehensive view of their functional mechanism and offer valuable insights regarding the development of antivirals. In this article, we provide an overview of the structural aspects of RdRps and their complexes from the Group III, IV and V viruses and their structure-based phylogeny.
Keywords: RNA viruses; RNA-dependent RNA polymerase; domains; motifs; structure-based Phylogeny; inhibitor complexes RNA viruses; RNA-dependent RNA polymerase; domains; motifs; structure-based Phylogeny; inhibitor complexes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Venkataraman, S.; Prasad, B.V.L.S.; Selvarajan, R. RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution. Viruses 2018, 10, 76.

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