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Viruses 2018, 10(2), 69; https://doi.org/10.3390/v10020069

Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection

1
Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinay Medicine, Kasetsart University, Bangkok 10900, Thailand
2
Division of Molecular Medicine, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
3
Division of Molecular Medicine, Office for Research and Development, 4th Floor SiMR Building, 2 Wanglang Road, Faculty of Medicine Siriraj Hospital, Bangkoknoi, Bangkok 10700, Thailand
*
Authors to whom correspondence should be addressed.
Received: 14 December 2017 / Revised: 19 January 2018 / Accepted: 1 February 2018 / Published: 8 February 2018
(This article belongs to the Special Issue Cytoskeleton in Virus Infections)
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Abstract

The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage. Properly functioning endothelial cells promote physiological balance and stability for blood circulation and fluid components. A monolayer of endothelial cells has the ability to regulate paracellular and transcellular pathways for transport proteins, solutes, and fluid. In addition to the paracellular pathway, the transcellular pathway is another route of endothelial permeability that mediates vascular permeability under physiologic conditions. The transcellular pathway was found to be associated with an assortment of disease pathogeneses. The clinical manifestation of severe dengue infection in humans is vascular leakage and hemorrhagic diatheses. This review explores and describes the transcellular pathway, which is an alternate route of vascular permeability during dengue infection that corresponds with the pathologic finding of intact tight junction. This pathway may be the route of albumin transport that causes endothelial dysfunction during dengue virus infection. View Full-Text
Keywords: Thailand; transcytosis; transport system; endothelial permeability; vascular leakage; dengue virus infection Thailand; transcytosis; transport system; endothelial permeability; vascular leakage; dengue virus infection
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Chanthick, C.; Suttitheptumrong, A.; Rawarak, N.; Pattanakitsakul, S.-N. Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection. Viruses 2018, 10, 69.

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