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Viruses 2009, 1(3), 818-831; doi:10.3390/v1030818

Hepatitis Delta Virus RNA Replication

1 and 1,2,3,*
1 Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan 2 Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA 3 National Cheng-Kung University, Tainan 701, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 September 2009 / Revised: 3 November 2009 / Accepted: 3 November 2009 / Published: 6 November 2009
(This article belongs to the Special Issue Subviral RNAs)
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Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen (HDAg), which is indispensible for HDV replication, is a unique feature distinct from plant viroids, which do not encode any protein. Here the HDV RNA replication cycle is reviewed, with emphasis on the function of HDAg in modulating RNA replication and the nature of the enzyme involved.
Keywords: hepatitis delta virus; hepatitis delta antigen; RNA-dependent RNA synthesis; RNA polymerases; RNA replication hepatitis delta virus; hepatitis delta antigen; RNA-dependent RNA synthesis; RNA polymerases; RNA replication
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tseng, C.-H.; Lai, M.M.C. Hepatitis Delta Virus RNA Replication. Viruses 2009, 1, 818-831.

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