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Materials 2016, 9(9), 763; doi:10.3390/ma9090763

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

1
Institute of Science and Technology for Ceramics, National Research Council of Italy, Via Granarolo 64, Faenza 48018, Italy
2
Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F Vito, 1, Rome 00168, Italy
3
Latium Musculoskeletal Tissue Bank, Largo F Vito, 1, Rome 00168, Italy
4
Orthopaedics and Traumatology, Università Cattolica del Sacro Cuore, Largo F Vito, 1, Rome 00168, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Enrico Bernardo
Received: 8 July 2016 / Revised: 29 August 2016 / Accepted: 2 September 2016 / Published: 8 September 2016
(This article belongs to the Special Issue Bioceramics 2016)
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Abstract

The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration. View Full-Text
Keywords: bone cement; hydroxyapatite; strontium; alginate; in vivo; osteointegration bone cement; hydroxyapatite; strontium; alginate; in vivo; osteointegration
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MDPI and ACS Style

Sprio, S.; Dapporto, M.; Montesi, M.; Panseri, S.; Lattanzi, W.; Pola, E.; Logroscino, G.; Tampieri, A. Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate. Materials 2016, 9, 763.

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