Pickering Emulsion-Based Marbles for Cellular Capsules
AbstractThe biodegradable cellular capsule, being prepared from simple vaporization of liquid marbles, is an ideal vehicle for the potential application of drug encapsulation and release. This paper reports the fabrication of cellular capsules via facile vaporization of Pickering emulsion marbles in an ambient atmosphere. Stable Pickering emulsion (water in oil) was prepared while utilizing dichloromethane (containing poly(l-lactic acid)) and partially hydrophobic silica particles as oil phase and stabilizing agents respectively. Then, the Pickering emulsion marbles were formed by dropping emulsion into a petri dish containing silica particles with a syringe followed by rolling. The cellular capsules were finally obtained after the complete vaporization of both oil and water phases. The technique of scanning electron microscope (SEM) was employed to research the microstructure and surface morphology of the prepared capsules and the results showed the cellular structure as expected. An in vitro drug release test was implemented which showed a sustained release property of the prepared cellular capsules. In addition, the use of biodegradable poly(l-lactic acid) and the biocompatible silica particles also made the fabricated cellular capsules of great potential in the application of sustained drug release. View Full-Text
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Zhang, G.; Wang, C. Pickering Emulsion-Based Marbles for Cellular Capsules. Materials 2016, 9, 572.
Zhang G, Wang C. Pickering Emulsion-Based Marbles for Cellular Capsules. Materials. 2016; 9(7):572.Chicago/Turabian Style
Zhang, Guangzhao; Wang, Chaoyang. 2016. "Pickering Emulsion-Based Marbles for Cellular Capsules." Materials 9, no. 7: 572.
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