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Materials 2016, 9(7), 572; doi:10.3390/ma9070572

Pickering Emulsion-Based Marbles for Cellular Capsules

Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China
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Academic Editor: To Ngai
Received: 27 June 2016 / Revised: 6 July 2016 / Accepted: 7 July 2016 / Published: 14 July 2016
(This article belongs to the Special Issue Pickering Emulsion and Derived Materials)
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Abstract

The biodegradable cellular capsule, being prepared from simple vaporization of liquid marbles, is an ideal vehicle for the potential application of drug encapsulation and release. This paper reports the fabrication of cellular capsules via facile vaporization of Pickering emulsion marbles in an ambient atmosphere. Stable Pickering emulsion (water in oil) was prepared while utilizing dichloromethane (containing poly(l-lactic acid)) and partially hydrophobic silica particles as oil phase and stabilizing agents respectively. Then, the Pickering emulsion marbles were formed by dropping emulsion into a petri dish containing silica particles with a syringe followed by rolling. The cellular capsules were finally obtained after the complete vaporization of both oil and water phases. The technique of scanning electron microscope (SEM) was employed to research the microstructure and surface morphology of the prepared capsules and the results showed the cellular structure as expected. An in vitro drug release test was implemented which showed a sustained release property of the prepared cellular capsules. In addition, the use of biodegradable poly(l-lactic acid) and the biocompatible silica particles also made the fabricated cellular capsules of great potential in the application of sustained drug release. View Full-Text
Keywords: Pickering emulsion; liquid marbles; cellular capsule; drug release; biodegradable Pickering emulsion; liquid marbles; cellular capsule; drug release; biodegradable
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, G.; Wang, C. Pickering Emulsion-Based Marbles for Cellular Capsules. Materials 2016, 9, 572.

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