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Materials 2016, 9(4), 225; doi:10.3390/ma9040225

Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification

Institute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland
Food Chemistry Unit, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Schuhstr. 19, 91052 Erlangen, Germany
Author to whom correspondence should be addressed.
Academic Editor: Gigliola Lusvardi
Received: 6 February 2016 / Revised: 15 March 2016 / Accepted: 15 March 2016 / Published: 24 March 2016
(This article belongs to the Special Issue Bioactive Glasses)
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Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications. View Full-Text
Keywords: bioactive glass nanoparticle; bioactivity; silver; surface modification; antibacterial activity bioactive glass nanoparticle; bioactivity; silver; surface modification; antibacterial activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kozon, D.; Zheng, K.; Boccardi, E.; Liu, Y.; Liverani, L.; Boccaccini, A.R. Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification. Materials 2016, 9, 225.

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