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Materials 2016, 9(3), 135; doi:10.3390/ma9030135

Alendronate Functionalized Mesoporous Bioactive Glass Nanospheres

1
Department of Chemistry “G. Ciamician”, University of Bologna, Via Selmi 2, Bologna 40126, Italy
2
Institute of Science and Technology for Ceramics, National Research Council of Italy, Via Granarolo 64, Faenza 48018, Italy
3
Laboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago 8380492, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Gigliola Lusvardi
Received: 21 December 2015 / Revised: 11 February 2016 / Accepted: 18 February 2016 / Published: 26 February 2016
(This article belongs to the Special Issue Bioactive Glasses)
View Full-Text   |   Download PDF [1971 KB, uploaded 26 February 2016]   |  

Abstract

In this work we synthesized mesoporous bioactive glass nanospheres (nMBG) with the aim to utilize them as substrates for loading one of the most potent amino-bisphosphonates, alendronate (AL). The results of the chemical and structural characterization show that the nMBG display a relatively high surface area (528 m2/g) and a mean pore volume of 0.63 cm3/g, both of which decrease on increasing alendronate content. It is possible to modulate the amount of AL loaded into the nanospheres up to a maximum value of about 17 wt %. In vitro tests were performed using a human osteosarcoma cell line (MG63) and a murine monocyte/macrophage cell line as osteoclast model (RAW 264.7). The results indicate that even the lower concentration of alendronate provokes decreased tumor cell viability, and that osteoclast activity exhibits an alendronate dose-dependent inhibition. The data suggest that nMBG can act as a suitable support for the local delivery of alendronate, and that the antiresorptive and antitumor properties of the functionalized mesoporous nanospheres can be modulated by varying the amount of alendronate loading. View Full-Text
Keywords: mesoporous; bioactive glass nanospheres; alendronate; osteoclast inhibition; anti-cancer mesoporous; bioactive glass nanospheres; alendronate; osteoclast inhibition; anti-cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Boanini, E.; Panseri, S.; Arroyo, F.; Montesi, M.; Rubini, K.; Tampieri, A.; Covarrubias, C.; Bigi, A. Alendronate Functionalized Mesoporous Bioactive Glass Nanospheres. Materials 2016, 9, 135.

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