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Materials 2015, 8(4), 1482-1498; doi:10.3390/ma8041482

Tribo-electrification and Powder Adhesion Studies in the Development of Polymeric Hydrophilic Drug Matrices

1
Department of Pharmacy, University of Huddersfield, Huddersfield HD1 3DH, UK
2
Department of Chemical Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Loo Say Chye Joachim
Received: 1 March 2015 / Revised: 19 March 2015 / Accepted: 23 March 2015 / Published: 30 March 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
View Full-Text   |   Download PDF [2104 KB, uploaded 30 March 2015]   |  

Abstract

The generation of tribo-electric charge during pharmaceutical powder processing can cause a range of complications, including segregation of components leading to content uniformity and particle surface adhesion. This phenomenon becomes problematical when excipients are introduced to a powder mixture alongside the highly charging active pharmaceutical ingredient(s) (APIs). The aim of this study was to investigate the tribo-electric charging and adhesion properties of a model drug, theophylline. Moreover, binary powder mixtures of theophylline with methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), having different polymer to drug ratios, were formed in order to study the impact of polymer concentration, particle size, substitution ratio and molecular size on the tribo-electric charging and surface adhesion properties of the drug. Furthermore, the relationship between tribo-electric charging and surface adhesion was also studied. The diversity in physicochemical properties of MC/HPMC has shown a significant impact on the tribo-electric charging and adhesion behaviour of theophylline. It was found that the magnitude of electrostatic charge and the level of surface adhesion of the API were significantly reduced with an increase in MC and HPMC concentration, substitution ratios and molecular size. In addition, the tribo-electric charge showed a linear relationship with particle surface adhesion, but the involvement of other forces cannot be neglected. View Full-Text
Keywords: tribo-electric charging; hydroxypropyl methylcellulose; methylcellulose; surface adhesion; theophylline tribo-electric charging; hydroxypropyl methylcellulose; methylcellulose; surface adhesion; theophylline
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ghori, M.U.; Šupuk, E.; Conway, B.R. Tribo-electrification and Powder Adhesion Studies in the Development of Polymeric Hydrophilic Drug Matrices. Materials 2015, 8, 1482-1498.

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