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Materials 2015, 8(3), 832-849; doi:10.3390/ma8030832

Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar 470 003, (MP), India
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Author to whom correspondence should be addressed.
Academic Editor: Loo Say Chye Joachim
Received: 13 January 2015 / Revised: 6 February 2015 / Accepted: 13 February 2015 / Published: 27 February 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
View Full-Text   |   Download PDF [817 KB, uploaded 27 February 2015]   |  

Abstract

In the present study, Eudragit S100 coated Citrus Pectin Nanoparticles (E-CPNs) were prepared for the colon targeting of 5-Fluorouracil (5-FU). Citrus pectin also acts as a ligand for galectin-3 receptors that are over expressed on colorectal cancer cells. Nanoparticles (CPNs and E-CPNs) were characterized for various physical parameters such as particle size, size distribution, and shape etc. In vitro drug release studies revealed selective drug release in the colonic region in the case of E-CPNs of more than 70% after 24 h. In vitro cytoxicity assay (Sulphorhodamine B assay) was performed against HT-29 cancer cells and exhibited 1.5 fold greater cytotoxicity potential of nanoparticles compared to 5-FU solution. In vivo data clearly depicted that Eudragit S100 successfully guarded nanoparticles to reach the colonic region wherein nanoparticles were taken up and showed drug release for an extended period of time. Therefore, a multifaceted strategy is introduced here in terms of receptor mediated uptake and pH-dependent release using E-CPNs for effective chemotherapy of colorectal cancer with uncompromised safety and efficacy. View Full-Text
Keywords: Eudragit S100; citrus pectin; 5-Fluorouracil; colon targeting; cancer Eudragit S100; citrus pectin; 5-Fluorouracil; colon targeting; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Subudhi, M.B.; Jain, A.; Jain, A.; Hurkat, P.; Shilpi, S.; Gulbake, A.; Jain, S.K. Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil. Materials 2015, 8, 832-849.

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