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Materials 2014, 7(7), 5366-5384; doi:10.3390/ma7075366

Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs

*  and
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China
* Author to whom correspondence should be addressed.
Received: 23 May 2014 / Revised: 10 June 2014 / Accepted: 14 July 2014 / Published: 23 July 2014
(This article belongs to the Special Issue Advanced Nanomaterials for Biosensors)
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MicroRNAs (miRNAs) play important functions in post-transcriptional regulation of gene expression. They have been regarded as reliable molecular biomarkers for many diseases including cancer. However, the content of miRNAs in cells can be low down to a few molecules per cell. Thus, highly sensitive analytical methods for miRNAs detection are desired. Recently, electrochemical biosensors have held great promise as devices suitable for point-of-care diagnostics and multiplexed platforms for fast, simple and low-cost nucleic acid analysis. Signal amplification by nanomaterials is one of the most popular strategies for developing ultrasensitive assay methods. This review surveys the latest achievements in the use of nanomaterials to detect miRNAs with a focus on electrochemical techniques.
Keywords: nanomaterials; miRNAs; electrochemistry; biosensors nanomaterials; miRNAs; electrochemistry; biosensors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xia, N.; Zhang, L. Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs. Materials 2014, 7, 5366-5384.

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