Materials 2014, 7(7), 5366-5384; doi:10.3390/ma7075366
Review

Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs

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Received: 23 May 2014; in revised form: 10 June 2014 / Accepted: 14 July 2014 / Published: 23 July 2014
(This article belongs to the Special Issue Advanced Nanomaterials for Biosensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: MicroRNAs (miRNAs) play important functions in post-transcriptional regulation of gene expression. They have been regarded as reliable molecular biomarkers for many diseases including cancer. However, the content of miRNAs in cells can be low down to a few molecules per cell. Thus, highly sensitive analytical methods for miRNAs detection are desired. Recently, electrochemical biosensors have held great promise as devices suitable for point-of-care diagnostics and multiplexed platforms for fast, simple and low-cost nucleic acid analysis. Signal amplification by nanomaterials is one of the most popular strategies for developing ultrasensitive assay methods. This review surveys the latest achievements in the use of nanomaterials to detect miRNAs with a focus on electrochemical techniques.
Keywords: nanomaterials; miRNAs; electrochemistry; biosensors
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MDPI and ACS Style

Xia, N.; Zhang, L. Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs. Materials 2014, 7, 5366-5384.

AMA Style

Xia N, Zhang L. Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs. Materials. 2014; 7(7):5366-5384.

Chicago/Turabian Style

Xia, Ning; Zhang, Liping. 2014. "Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs." Materials 7, no. 7: 5366-5384.

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