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Materials 2013, 6(11), 5038-5046; doi:10.3390/ma6115038
Article

A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection

* ,
,
 and
State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
* Author to whom correspondence should be addressed.
Received: 7 October 2013 / Revised: 25 October 2013 / Accepted: 25 October 2013 / Published: 1 November 2013
(This article belongs to the Special Issue Functional Materials and Proteins for Bio-Sensing Applications)
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Abstract

A DNAzyme-based sensor for the determination and quantification of lead ions (Pb2+) has been established, which combines the recognition and catalysis of DNAzyme with the optical properties of nanomaterials. Circular dichroism (CD) signals were obtained by a DNAzyme-based assembly of asymmetric silver nanoparticle (AgNPs) dimers. A good linear relationship between CD signals and Pb2+ concentration was obtained ranging from 0.05 ng∙mL−1 to 10 ng∙mL−1 with a limit of detection (LOD) of 0.02 ng∙mL−1. The specificity of this sensor in lead ion detection was excellent, and a satisfactory recovery was obtained in the analysis of tap water samples. The proposed technique possesses both high sensitivity and good specificity, giving it great potential for the analysis of Pb2+ in water.
Keywords: lead; detection; DNAzyme; circular dichroism (CD); sensor lead; detection; DNAzyme; circular dichroism (CD); sensor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kuang, H.; Yin, H.; Xing, C.; Xu, C. A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection. Materials 2013, 6, 5038-5046.

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