Next Article in Journal
Crystallization of Electrodeposited Germanium Thin Film on Silicon (100)
Next Article in Special Issue
Development of Conductive Boron-Doped Diamond Electrode: A microscopic, Spectroscopic, and Voltammetric Study
Previous Article in Journal
Microstructure of Haynes® 282® Superalloy after Vacuum Induction Melting and Investment Casting of Thin-Walled Components
Previous Article in Special Issue
Influence of a Thiolate Chemical Layer on GaAs (100) Biofunctionalization: An Original Approach Coupling Atomic Force Microscopy and Mass Spectrometry Methods
Article Menu

Export Article

Open AccessArticle
Materials 2013, 6(11), 5038-5046; doi:10.3390/ma6115038

A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection

State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
Author to whom correspondence should be addressed.
Received: 7 October 2013 / Revised: 25 October 2013 / Accepted: 25 October 2013 / Published: 1 November 2013
(This article belongs to the Special Issue Functional Materials and Proteins for Bio-Sensing Applications)
View Full-Text   |   Download PDF [390 KB, uploaded 1 November 2013]   |  


A DNAzyme-based sensor for the determination and quantification of lead ions (Pb2+) has been established, which combines the recognition and catalysis of DNAzyme with the optical properties of nanomaterials. Circular dichroism (CD) signals were obtained by a DNAzyme-based assembly of asymmetric silver nanoparticle (AgNPs) dimers. A good linear relationship between CD signals and Pb2+ concentration was obtained ranging from 0.05 ng∙mL−1 to 10 ng∙mL−1 with a limit of detection (LOD) of 0.02 ng∙mL−1. The specificity of this sensor in lead ion detection was excellent, and a satisfactory recovery was obtained in the analysis of tap water samples. The proposed technique possesses both high sensitivity and good specificity, giving it great potential for the analysis of Pb2+ in water.
Keywords: lead; detection; DNAzyme; circular dichroism (CD); sensor lead; detection; DNAzyme; circular dichroism (CD); sensor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kuang, H.; Yin, H.; Xing, C.; Xu, C. A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection. Materials 2013, 6, 5038-5046.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top