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Materials 2013, 6(11), 5038-5046; doi:10.3390/ma6115038

A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection

* ,
State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
* Author to whom correspondence should be addressed.
Received: 7 October 2013 / Revised: 25 October 2013 / Accepted: 25 October 2013 / Published: 1 November 2013
(This article belongs to the Special Issue Functional Materials and Proteins for Bio-Sensing Applications)
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A DNAzyme-based sensor for the determination and quantification of lead ions (Pb2+) has been established, which combines the recognition and catalysis of DNAzyme with the optical properties of nanomaterials. Circular dichroism (CD) signals were obtained by a DNAzyme-based assembly of asymmetric silver nanoparticle (AgNPs) dimers. A good linear relationship between CD signals and Pb2+ concentration was obtained ranging from 0.05 ng∙mL−1 to 10 ng∙mL−1 with a limit of detection (LOD) of 0.02 ng∙mL−1. The specificity of this sensor in lead ion detection was excellent, and a satisfactory recovery was obtained in the analysis of tap water samples. The proposed technique possesses both high sensitivity and good specificity, giving it great potential for the analysis of Pb2+ in water.
Keywords: lead; detection; DNAzyme; circular dichroism (CD); sensor lead; detection; DNAzyme; circular dichroism (CD); sensor
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuang, H.; Yin, H.; Xing, C.; Xu, C. A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection. Materials 2013, 6, 5038-5046.

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