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Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers
Department of Biology, University of Texas Arlington, Arlington, TX 76019,USA
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410,USA
Department of Biological Sciences, University of North Texas, Denton, TX 76203,USA
Department of Biology, Boston University, Boston, MA 02215, USA
* Author to whom correspondence should be addressed.
Received: 26 April 2011; in revised form: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011
Abstract: Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.
Keywords: organotins; antivirals; antitumor activity; polymers; dibutyltin; kinetin; diethylstilbestrol; dienestrol; platinum-containing polymers; cisplatin; tilorone; methotrexate
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MDPI and ACS Style
Roner, M.R.; Carraher Jr., C.E.; Shahi, K.; Barot, G. Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers. Materials 2011, 4, 991-1012.
Roner MR, Carraher Jr. CE, Shahi K, Barot G. Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers. Materials. 2011; 4(6):991-1012.
Roner, Michael R.; Carraher Jr., Charles E.; Shahi, Kimberly; Barot, Girish. 2011. "Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers." Materials 4, no. 6: 991-1012.