Next Article in Journal
Synthesis and Properties of a Chiroptically Active Oligomer from 3,4-Ethylenedioxythiophene and (–)-Myrtenal
Previous Article in Journal
Luminescent Afterglow Behavior in the M2Si5N8: Eu Family (M = Ca, Sr, Ba)
Previous Article in Special Issue
Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro
Materials 2011, 4(6), 991-1012; doi:10.3390/ma4060991
Review

Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers

1,* , 2,3
,
4
 and
5
Received: 26 April 2011 / Revised: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011
(This article belongs to the Special Issue Metal-Containing Polymers)
Download PDF [252 KB, uploaded 27 May 2011]

Abstract

Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.
Keywords: organotins; antivirals; antitumor activity; polymers; dibutyltin; kinetin; diethylstilbestrol; dienestrol; platinum-containing polymers; cisplatin; tilorone; methotrexate organotins; antivirals; antitumor activity; polymers; dibutyltin; kinetin; diethylstilbestrol; dienestrol; platinum-containing polymers; cisplatin; tilorone; methotrexate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Roner, M.R.; Carraher Jr., C.E.; Shahi, K.; Barot, G. Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers. Materials 2011, 4, 991-1012.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert