Materials 2011, 4(4), 801-815; doi:10.3390/ma4040801
Article

Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro

Charles E. Carraher Jr. 1,2 email, Michael R. Roner 3,* email, Kimberly Shahi 4 email and Girish Barot 5 email
1 Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA 2 Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA 3 Department of Biology, University of Texas Arlington, Arlington, TX 76019, USA 4 Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA 5 Department of Biology, Boston University, Boston, MA 02215, USA
* Author to whom correspondence should be addressed.
Received: 11 February 2011; in revised form: 4 April 2011 / Accepted: 8 April 2011 / Published: 15 April 2011
(This article belongs to the Special Issue Metal-Containing Polymers)
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Abstract: The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.
Keywords: tin-containing polymers; cancer; breast cancer; organotin compounds; organotin polyethers; estrogen receptor positive breast cancer; estrogen-independent breast cancer

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MDPI and ACS Style

Carraher Jr., C.E.; Roner, M.R.; Shahi, K.; Barot, G. Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro. Materials 2011, 4, 801-815.

AMA Style

Carraher Jr. CE, Roner MR, Shahi K, Barot G. Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro. Materials. 2011; 4(4):801-815.

Chicago/Turabian Style

Carraher Jr., Charles E.; Roner, Michael R.; Shahi, Kimberly; Barot, Girish. 2011. "Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro." Materials 4, no. 4: 801-815.

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