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Materials 2011, 4(10), 1818-1834; doi:10.3390/ma4101818

Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner

1, 1,2, 1 and 1,*
1 Department of Radiological Sciences, University of California, Los Angeles, CA 90095, USA 2 Medical Imaging Informatics (MII) Lab, University of California, Los Angeles, CA 90095, USA
* Author to whom correspondence should be addressed.
Received: 2 September 2011 / Revised: 6 October 2011 / Accepted: 7 October 2011 / Published: 17 October 2011
(This article belongs to the Special Issue High Field Magnetic Resonance Methods and Materials)
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The use of spin-echoes has been employed in an Echo-Planar Spectroscopic Imaging (EPSI) sequence to collect multiple phase encoded lines within a single TR in a Multi-Echo-based Echo-Planar Spectroscopic Imaging technique (MEEPSI). Despite the T2 dependence on the amplitude of the spin-echoes, the Full Width at Half Maximum (FWHM) of the derived multi-echo Point Spread Function (PSF) is shown to decrease, indicating an improved overall spatial resolution without requiring any additional scan time. The improved spatial resolution is demonstrated in the one-dimensional (1D) spatial profiles of the N-Acetyl Aspartate (NAA) singlet along the phase encode dimension in a gray matter phantom. Although the improved spatial resolution comes at the expense of spectral resolution, it is shown in vivo that peak broadening due to T2* decay is more significant than the loss of resolution from using spin-echoes and therefore does not affect the ability to quantify metabolites using the LCModel fitting algorithm.
Keywords: multi-echo; echo-planar spectroscopic imaging multi-echo; echo-planar spectroscopic imaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Furuyama, J.K.; Burns, B.L.; Wilson, N.E.; Thomas, M.A. Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner. Materials 2011, 4, 1818-1834.

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