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Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner
Department of Radiological Sciences, University of California, Los Angeles, CA 90095, USA
Medical Imaging Informatics (MII) Lab, University of California, Los Angeles, CA 90095, USA
* Author to whom correspondence should be addressed.
Received: 2 September 2011; in revised form: 6 October 2011 / Accepted: 7 October 2011 / Published: 17 October 2011
Abstract: The use of spin-echoes has been employed in an Echo-Planar Spectroscopic Imaging (EPSI) sequence to collect multiple phase encoded lines within a single TR in a Multi-Echo-based Echo-Planar Spectroscopic Imaging technique (MEEPSI). Despite the T2 dependence on the amplitude of the spin-echoes, the Full Width at Half Maximum (FWHM) of the derived multi-echo Point Spread Function (PSF) is shown to decrease, indicating an improved overall spatial resolution without requiring any additional scan time. The improved spatial resolution is demonstrated in the one-dimensional (1D) spatial profiles of the N-Acetyl Aspartate (NAA) singlet along the phase encode dimension in a gray matter phantom. Although the improved spatial resolution comes at the expense of spectral resolution, it is shown in vivo that peak broadening due to T2* decay is more significant than the loss of resolution from using spin-echoes and therefore does not affect the ability to quantify metabolites using the LCModel fitting algorithm.
Keywords: multi-echo; echo-planar spectroscopic imaging
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Furuyama, J.K.; Burns, B.L.; Wilson, N.E.; Thomas, M.A. Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner. Materials 2011, 4, 1818-1834.
Furuyama JK, Burns BL, Wilson NE, Thomas MA. Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner. Materials. 2011; 4(10):1818-1834.
Furuyama, Jon K.; Burns, Brian L.; Wilson, Neil E.; Thomas, M. Albert. 2011. "Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner." Materials 4, no. 10: 1818-1834.