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Materials 2010, 3(3), 1845-1862; doi:10.3390/ma3031845

Application of Nanodiamonds in Biomolecular Mass Spectrometry

1
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA
2
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
3
The School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China
*
Author to whom correspondence should be addressed.
Received: 21 December 2009 / Revised: 11 February 2010 / Accepted: 12 March 2010 / Published: 15 March 2010
(This article belongs to the Special Issue The New Diamond Age?)
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Abstract

The combination of nanodiamond (ND) with biomolecular mass spectrometry (MS) makes rapid, sensitive detection of biopolymers from complex biosamples feasible. Due to its chemical inertness, optical transparency and biocompatibility, the advantage of NDs in MS study is unique. Furthermore, functionalization on the surfaces of NDs expands their application in the fields of proteomics and genomics for specific requirements greatly. This review presents methods of MS analysis based on solid phase extraction and elution on NDs and different application examples including peptide, protein, DNA, glycan and others. Owing to the quick development of nanotechnology, surface chemistry, new MS methods and the intense interest in proteomics and genomics, a huge increase of their applications in biomolecular MS analysis in the near future can be predicted.
Keywords: nanodiamonds; mass spectrometry; matrix assisted laser desorption/ionization; solid phase extraction; peptide; protein; DNA oligonucleotide; body fluid; non-covalent interaction; organic functionalization nanodiamonds; mass spectrometry; matrix assisted laser desorption/ionization; solid phase extraction; peptide; protein; DNA oligonucleotide; body fluid; non-covalent interaction; organic functionalization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kong, X.; Cheng, P. Application of Nanodiamonds in Biomolecular Mass Spectrometry. Materials 2010, 3, 1845-1862.

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