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Scaffold Characteristics for Functional Hollow Organ Regeneration
Laboratory for Urologic Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital, Zurich, Switzerland
Cells and Biomaterials, Department of Materials, ETH Zurich, Switzerland
Division of Pediatric Urology, Department of Pediatric Surgery, University Children‘s Hospital, Zurich, Switzerland
* Author to whom correspondence should be addressed.
Received: 10 December 2009; in revised form: 5 January 2010 / Accepted: 7 January 2010 / Published: 8 January 2010
Abstract: Many medical conditions require surgical reconstruction of hollow organs. Tissue engineering of organs and tissues is a promising new technique without harvest site morbidity. An ideal biomaterial should be biocompatible, support tissue formation and provide adequate structural support. It should degrade gradually and provide an environment allowing for cell-cell interaction, adhesion, proliferation, migration, and differentiation. Although tissue formation is feasible, functionality has never been demonstrated. Mainly the lack of proper innervation and vascularisation are hindering contractility and normal function. In this chapter we critically review the current state of engineering hollow organs with a special focus on innervation and vascularisation.
Keywords: scaffold; regeneration; tissue engineering; biomaterials; hollow organs; regenerative medicine
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MDPI and ACS Style
Horst, M.; Madduri, S.; Gobet, R.; Sulser, T.; Hall, H.; Eberli, D. Scaffold Characteristics for Functional Hollow Organ Regeneration. Materials 2010, 3, 241-263.
Horst M, Madduri S, Gobet R, Sulser T, Hall H, Eberli D. Scaffold Characteristics for Functional Hollow Organ Regeneration. Materials. 2010; 3(1):241-263.
Horst, Maya; Madduri, Srinivas; Gobet, Rita; Sulser, Tullio; Hall, Heike; Eberli, Daniel. 2010. "Scaffold Characteristics for Functional Hollow Organ Regeneration." Materials 3, no. 1: 241-263.