Next Article in Journal
On Micro-Macro Transition in Non-Linear Mechanics
Next Article in Special Issue
A Review of Keratin-Based Biomaterials for Biomedical Applications
Previous Article in Journal
Families of Molecular Hexa- and Trideca-Metallic Vanadium(III) Phosphonates
Previous Article in Special Issue
Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine
Article Menu

Export Article

Open AccessReview
Materials 2010, 3(1), 241-263; doi:10.3390/ma3010241

Scaffold Characteristics for Functional Hollow Organ Regeneration

1
Laboratory for Urologic Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital, Zurich, Switzerland
2
Cells and Biomaterials, Department of Materials, ETH Zurich, Switzerland
3
Division of Pediatric Urology, Department of Pediatric Surgery, University Children‘s Hospital, Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Received: 10 December 2009 / Revised: 5 January 2010 / Accepted: 7 January 2010 / Published: 8 January 2010
(This article belongs to the Special Issue Advances in Biomaterials)
View Full-Text   |   Download PDF [355 KB, uploaded 9 January 2010]

Abstract

Many medical conditions require surgical reconstruction of hollow organs. Tissue engineering of organs and tissues is a promising new technique without harvest site morbidity. An ideal biomaterial should be biocompatible, support tissue formation and provide adequate structural support. It should degrade gradually and provide an environment allowing for cell-cell interaction, adhesion, proliferation, migration, and differentiation. Although tissue formation is feasible, functionality has never been demonstrated. Mainly the lack of proper innervation and vascularisation are hindering contractility and normal function. In this chapter we critically review the current state of engineering hollow organs with a special focus on innervation and vascularisation.
Keywords: scaffold; regeneration; tissue engineering; biomaterials; hollow organs; regenerative medicine scaffold; regeneration; tissue engineering; biomaterials; hollow organs; regenerative medicine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Horst, M.; Madduri, S.; Gobet, R.; Sulser, T.; Hall, H.; Eberli, D. Scaffold Characteristics for Functional Hollow Organ Regeneration. Materials 2010, 3, 241-263.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top