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Materials 2009, 2(4), 1547-1557; doi:10.3390/ma2041547
When Blood Is Touched
Received: 7 September 2009; Accepted: 16 October 2009 / Published: 16 October 2009
(This article belongs to the Special Issue Advances in Biomaterials)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The development of blood-compatible materials is reviewed. It grew from originally simplistic views of physical requirements such as surface charge and wettability, to endothelial cells seeded onto a biodegradable cast, and tissue engineering. In vitro findings grew from the discovery of one specific protein being adsorbed, to that of sequential protein adsorption with complex implications of platelet and white cell adhesion. The main challenge is still the production of small blood vessels (capillaries).
Keywords: blood; surface; interface; biomaterial