Lateral Tension-Induced Penetration of Particles into a Liposome
AbstractIt is important that we understand the mechanism of the penetration of particles into a living cell to achieve advances in bionanotechnology, such as for treatment, visualization within a cell, and genetic modification. Although there have been many studies on the application of functional particles to cells, the basic mechanism of penetration across a biological membrane is still poorly understood. Here we used a model membrane system to demonstrate that lateral membrane tension drives particle penetration across a lipid bilayer. After the application of osmotic pressure, fully wrapped particles on a liposome surface were found to enter the liposome. We discuss the mechanism of the tension-induced penetration in terms of narrow constriction of the membrane at the neck part. The present findings are expected to provide insight into the application of particles to biological systems. View Full-Text
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Shigyou, K.; Nagai, K.H.; Hamada, T. Lateral Tension-Induced Penetration of Particles into a Liposome. Materials 2017, 10, 765.
Shigyou K, Nagai KH, Hamada T. Lateral Tension-Induced Penetration of Particles into a Liposome. Materials. 2017; 10(7):765.Chicago/Turabian Style
Shigyou, Kazuki; Nagai, Ken H.; Hamada, Tsutomu. 2017. "Lateral Tension-Induced Penetration of Particles into a Liposome." Materials 10, no. 7: 765.
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