Next Article in Journal
Carbon Nanostructure of Kraft Lignin Thermally Treated at 500 to 1000 °C
Next Article in Special Issue
Growth Description for Vessel Wall Adaptation: A Thick-Walled Mixture Model of Abdominal Aortic Aneurysm Evolution
Previous Article in Journal
Preparation and Characterization of Cyclotrimethylenetrinitramine (RDX) with Reduced Sensitivity
Previous Article in Special Issue
Lateral Tension-Induced Penetration of Particles into a Liposome
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Materials 2017, 10(8), 973; doi:10.3390/ma10080973

Genetically Engineered Phage Induced Selective H9c2 Cardiomyocytes Patterning in PDMS Microgrooves

Korea Institute of Science and Technology Europe (KIST-Europe) Forschungsgesellschaft mbH, Campus E 7 1, 66123 Saarbrücken, Germany
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Korea
Department of Biomedical Engineering, University of Science and Technology (UST), Daejeon 34113, Korea
Author to whom correspondence should be addressed.
Received: 7 July 2017 / Revised: 1 August 2017 / Accepted: 9 August 2017 / Published: 21 August 2017
(This article belongs to the Special Issue Constitutive Modelling of Biological Tissues and Biomaterials)
View Full-Text   |   Download PDF [4593 KB, uploaded 21 August 2017]   |  


A micro-patterned cell adhesive surface was prepared for future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro-patterns were prepared by a photolithography process. Afterwards, recombinant filamentous phages that displayed a short binding motif with a cell adhesive peptide (-RGD-) on p8 proteins were immobilized on PDMS microgrooves through simple contact printing to study the cellular response of rat H9c2 cardiomyocyte. While the cell density decreased on PDMS micro-patterns, we observed enhanced cell proliferation and cell to surface interaction on the RGD-phage coated PDMS microgrooves. The RGD-phage coating also supported a better alignment of cell spreading rather than isotropic cell growths as we observed on non-pattered PDMS surface. View Full-Text
Keywords: polydimethylsiloxane (PDMS); micro-patterns; RGD-phage; cell-surface interaction; rat H9c2 cardiomyocytes polydimethylsiloxane (PDMS); micro-patterns; RGD-phage; cell-surface interaction; rat H9c2 cardiomyocytes

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, Y.; Kwon, C.; Jeon, H. Genetically Engineered Phage Induced Selective H9c2 Cardiomyocytes Patterning in PDMS Microgrooves. Materials 2017, 10, 973.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top