Special Issue "Constitutive Modelling of Biological Tissues and Biomaterials"
Deadline for manuscript submissions: closed (31 October 2017)
Biological tissues demonstrate remarkably complex material behaviors, featuring aspects such as nonlinear stress–strain responses in case of soft tissues, anisotropy, viscoelasticity, and poroelasticity, all generally in large deformations. Most intriguing is the ability to adapt their composition and mechanical behavior in response to mechanical and biochemical stimuli. Understanding and having the ability to predict their material responses is essential towards understanding the physiological and pathological functionality of tissues within their in vivo contexts. Moreover, mathematical algorithms to predict how biological tissues adapt to changes in their environments are extremely valuable for understanding and predicting physiological adaptation and disease progression.
The earliest constitutive models to describe the material behavior of biological tissues mainly utilized phenomenological equations to relate the deformation to the stress state of the tissue. The advantages of this approach are that the results are relatively straightforward to interpret and it represents a computationally-efficient method to describe material responses. On the other hand, it is often difficult to assign a physiological meaning to material parameters, which complicates any interpretation in terms of biological mechanisms. The more recent developments of microstructurally-motivated constitutive models allow to dive deeper into the physical and biological principles of material behavior. In addition, the use of multiscale modeling is most likely inevitable for capturing phenomena occurring at different spatial and temporal scales. Specifically, the use of agent-based modeling opens up a wide range of opportunities for modeling biological processes that cannot be captured using a continuum framework.
Biomaterials are designed to interact with tissues inside the human body; as such, the development of constitutive models that describe their material responses is necessary to predict their functionality, and potentially also their effect on the material response and functionality of any surrounding tissues. Constitutive models are also essential here to optimize the performance of these materials with respect to the desired outcome.
It is our pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are welcome.
Dr.ir. S. (Sandra) Loerakker
Prof.dr.ir. F.P.T. (Frank) Baaijens
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- Constitutive models