Next Article in Journal
Strain Amount Dependent Grain Size and Orientation Developments during Hot Compression of a Polycrystalline Nickel Based Superalloy
Next Article in Special Issue
Effect of the Medium Composition on the Zn2+ Lixiviation and the Antifouling Properties of a Glass with a High ZnO Content
Previous Article in Journal
Uniaxial Negative Thermal Expansion and Mechanical Properties of a Zinc-Formate Framework
Previous Article in Special Issue
Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Materials 2017, 10(2), 153; doi:10.3390/ma10020153

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney 2006, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Enrico Bernardo
Received: 29 December 2016 / Revised: 30 January 2017 / Accepted: 4 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Bioceramics 2016)
View Full-Text   |   Download PDF [5447 KB, uploaded 13 February 2017]   |  

Abstract

Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the ionic substitution of calcium ions, the incorporation of metal oxides into the base binary xCaO–ySiO2 system, or a combination of both. Due to their unique compositions and ability to release bioactive ions, DCSCs exhibit enhanced mechanical and biological properties. Such characteristics offer significant advantages over existing ceramic bone substitutes, and underline the future potential of adopting DCSCs for clinical use in bone reconstruction to produce improved outcomes. This review will discuss the effects of different dopant elements and oxides on the characteristics of DCSCs for applications in bone repair, including mechanical properties, degradation and ion release characteristics, radiopacity, and biological activity (in vitro and in vivo). Recent advances in the development of DCSCs for broader clinical applications will also be discussed, including DCSC composites, coated DCSC scaffolds and DCSC-coated metal implants. View Full-Text
Keywords: calcium silicate; bioactive ceramic; synthetic bone substitute calcium silicate; bioactive ceramic; synthetic bone substitute
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

No, Y.J.; Li, J.J.; Zreiqat, H. Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes. Materials 2017, 10, 153.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top