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Materials 2017, 10(1), 83; doi:10.3390/ma10010083

Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration

1
CeRTEV—Center for Research, Technology and Education in Vitreous Materials, Vitreous Material Laboratory, Department of Materials Engineering, Universidade Federal de São Carlos—UFSCar, 13565905 São Carlos, SP, Brazil
2
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Enrico Bernardo
Received: 8 December 2016 / Revised: 12 January 2017 / Accepted: 13 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue Bioceramics 2016)
View Full-Text   |   Download PDF [6716 KB, uploaded 20 January 2017]   |  

Abstract

Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS–bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity. View Full-Text
Keywords: poly(glycerol sebacate); bioactive glass; fibers; composite; cartilage; tissue engineering poly(glycerol sebacate); bioactive glass; fibers; composite; cartilage; tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Souza, M.T.; Tansaz, S.; Zanotto, E.D.; Boccaccini, A.R. Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration. Materials 2017, 10, 83.

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